BMP15 and GDF9 gene mutations in premature ovarian failure

ABSTRACT

Background: Premature ovarian failure [POF] is an ovarian defect characterized by the premature depletion of ovarian follicles before the age of 40, representing one major cause of female infertility. Mutations in bone morphogenetic protein 15 [BMP15] and growth differentiation factor 9 [GDF9] have been shown to be associated with POF