[Bioinformatic evaluations for locating the microRNA suppressing PI3K/AKT pathway and analysis in prostate cancer cell lines]
Modares Journal of Medical Sciences, Pathobiology. 2015; 17 (4): 1-12
in Persian
| IMEMR
| ID: emr-185157
ABSTRACT
Objective:
Prostate cancer is the fifth most common cancer. In 2012, it was the second leading cause of cancer death for men worldwide. The PI3K/AKT pathway plays an essential role in pathogenesis of prostate cancer; the key role of this pathway in cancer progression makes it an attractive target for prostate cancer therapy. MicroRNAs [miRNAs] that regulate gene expression have a special ability to simultaneously control multiple genes and pathways which make them candidates for therapeutics. This study aims to determine miRNAs which target the PI3K/AKT pathway and evaluate them in prostate cancer cell lines
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Index:
IMEMR (Eastern Mediterranean)
Language:
Persian
Journal:
Modares J. Med. Sci., Pathobiol.
Year:
2015
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