[Evaluation of poly [amidoamine] dendrimer surface modification with poly[ethylene glycol] on cytotoxicity reduction]
Modares Journal of Medical Sciences, Pathobiology. 2015; 18 (1): 23-38
in Persian
| IMEMR
| ID: emr-185166
ABSTRACT
Objective:
Generation 5 poly [amidoamine] dendrimers are promising multipotent gene delivery vectors that provide favorable DNA condensation properties; however, their high toxicity limits their applications. Toxicity of PAMAM dendrimers depends on their type, generation and applied dosage in a way that lower generations [lower than G5 dendrimers] and anionic dendrimers have lower toxicity than higher generations and cationic dendrimers. The aim of this study is to evaluate the effect of PEGylation on toxicity of G5 PAMAM dendrimers
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Index:
IMEMR (Eastern Mediterranean)
Language:
Persian
Journal:
Modares J. Med. Sci., Pathobiol.
Year:
2015
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