[Evaluation of BALB/c mice antibody responses to two variant forms of plasmodium vivax apical membrane antigen-1 recombinant protein as a malaria vaccine candidate]

ABSTRACT

Objective: Apical membrane antigen-1 [AMA-1] is one of the most promising bloodstage candidate antigens for production of a malaria vaccine against the Plasmodium parasite. Genetic diversity in protective antigens, which is a common phenomenon in a complex pathogen such as the Plasmodium parasite, is responsible for problems with the development of an effective malaria vaccine. This phenomenon will increase the parasite's ability to evade immune responses. Therefore, malaria vaccine development requires the evaluation of immune responses to different allelic forms of the vaccine candidate antigens