[Transduction of mesenchymal stem cells that express VEGF-A and pre-conditioning with SDF1alpha In order to increase survival for use in myocardial infarction treatment in a rat model]

ABSTRACT

Objective: The use of stem cells, particularly mesenchymal stem cells [MSCs], with genes and various growth factors as treatments for myocardial infarction and various other diseases is highly regarded. However these cells meet with inflammation and a hypoxic environment in the target tissue. Hence, treatment with factors that increase the resistance of these stem cells is of importance. Stem cells also can be used as carriers for gene therapy. The aim of the present research is to produce VEGF expressing MSCs. We investigate the effect of stromal derived factor 1 on MSC survival in order to use these cells in a future rat myocardial infarction model