[Study of loading, cytotoxicity, uptake, and release of curcumin from a novel gemini surfactant nanocarrier]

ABSTRACT

Objective: Numerous researches have been conducted to comprehend the anti-cancer effects of curcumin [Cu]. Although the anti-proliferative properties of Cu on cancerous cells is known, the clinical application of this gold substrate is limited. This limitation is mostly due to low solubility, inefficient bioavailability, rapid metabolism, and improper uptake. In this study, we have synthesized a novel biodegradable gemini surfactant [Gs], after which the curcumin [Cu] molecules were encapsulated within the polymer to overcome its physicochemical limitations: