[ effect of 4 weeks resistance training on MuRF1 gene expression and muscle atrophy in diabetic wistar rats]

ABSTRACT

Background and Objectives: Muscular atrophy is one of the most common complications of diabetes. In such cases, protein degradation isincreased and protein synthesisis decreased. MuRF1 is an E3 ubiquitin ligase which has been identified as a mediator of skeletal muscle wasting in various skeletal muscle atrophy models, and its expression is upregulated in atrophy. Exercise training has been suggested as one of the treatment strategies for muscular atrophy. The aim of this study is to investigate the effects of 4 weeks of resistance training on MuRF1 gene expression in muscular atrophy in streptozotocin-diabetic wistar rats