Evaluation of the effect of benzodiazepines and D-tubocurarine on succinylcholineinduced fasciculations and myalgia

ABSTRACT

To determine the effectiveness of diazepam. midazolam and d. tubocurarine DTC preinduction [pretreatrment] in preventing succinyl - choline . induced fasciculations and post operative myalgia, 36 surgical patients were randomly allocated into four groups receiving either saline, DTC 0.05mg / Kg., diazepam 0.15 mg / Kg or midazolam 0.1 mg / Kg. Neither benzodiazepines influenced the incidence or severity of fasciculations and post operative myalgia. D-tubocurarine virtually abolished visible fasciculations and reduced the intensity of myalgia. There were statistical significant rise of serum K in benzodiazepine groups with no clinically significant importance