Analgesic and anti-inflammatory activity of aqueous-methanolic extract of Aerva javanica

ABSTRACT

The present study was aimed to investigate the analgesic and anti-inflammatory activity of aqueous methanolic extract of Aerva javanica. For measuring analgesic activity, writhing test, hot plate method and formalin test were performed and abdominal writhing was induced by intra-peritoneal injection of 0.2ml of 3% acetic acid. While in formalin test, pain was experimentally induced by injecting 25 micro l of 2.5% formalin in left hind paw. In hot plate method, pain was induced thermally by keeping the animals on a hot plate with temperature of about 51[degree]C. Anti-inflammatory activity was assessed by carrageen an induced mice paw edema. The results showed that the extract had significant analgesic activity [p<0.05- p<0.001] and anti-inflammatory activity [p<0.01-p<0.001]. Therefore, it was concluded from this study that the extracts of Aerva javanica may be used against pain and inflammation