Effects of low frequency stimulation on spontaneous inhibitory and excitatory post-synaptic currents in hippocampal CA1 pyramidal cells of kindled rats

Samireh, Ghafouri; Yaghoub, Fathollahi; Saeed, Semnanian; Amir, Shojaei; Zadeh, Mirnajafi

Samireh, Ghafouri; Yaghoub, Fathollahi; Saeed, Semnanian; Amir, Shojaei; Zadeh, Mirnajafi.

Cell Journal [Yakhteh]. 2017; 18 (4): 547-555

in English | IMEMR | ID: emr-185780

ABSTRACT

ABSTRACT

Objective:

Low-frequency stimulation [LFS] exerts suppressive effects in kindled animals. It is believed that overstimulated glutamatergic and decreased GABAergic transmission have long been associated with seizure activity. In this study, we investigated the effect of electrical LFS on different parameters of spontaneous excitatory and inhibitory post-synaptic currents [sEPSCs and sIPSCs] in hippocampal CA1 pyramidal cells in kindled animals

Subject(s)

Animals, Laboratory; Male; CA1 Region, Hippocampal; Pyramidal Cells; Inhibitory Postsynaptic Potentials; Excitatory Postsynaptic Potentials; Seizures/therapy; Rats, Wistar

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Index: IMEMR (Eastern Mediterranean) Main subject: Seizures / Rats, Wistar / Pyramidal Cells / Excitatory Postsynaptic Potentials / Inhibitory Postsynaptic Potentials / CA1 Region, Hippocampal Limits: Animals Language: English Journal: Cell J. [Yakhteh] Year: 2017

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