Micro-environmental signature of the interactions between druggable target protein, dipeptidyl peptidase-IV, and anti-diabetic drugs
Cell Journal [Yakhteh]. 2017; 19 (1): 65-83
in English
| IMEMR
| ID: emr-185794
ABSTRACT
Objective:
Druggability of a target protein depends on the interacting micro-environment between the target protein and drugs. Therefore, a precise knowledge of the interacting micro-environment between the target protein and drugs is requisite for drug discovery process. To understand such micro-environment, we performed in silico interaction analysis between a human target protein, Dipeptidyl Peptidase-IV [DPP-4], and three anti-diabetic drugs [saxagliptin, linagliptin and vildagliptin]
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Protein Binding
/
Models, Molecular
/
Dipeptidyl Peptidase 4
/
Dipeptidyl-Peptidase IV Inhibitors
/
Drug Discovery
/
Molecular Targeted Therapy
Limits:
Humans
Language:
English
Journal:
Cell J. [Yakhteh]
Year:
2017
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