<The> effects of berberine and palmatine on efflux pumps inhibition with different gene patterns in Pseudomonas aeruginosa isolated from burn infections

Seyed, Aghayan; Hamidreza, Mogadam; Mozhgan, Fazli; Davood, Darban Sarokhalil; Seyed, Khoramrooz; Fereshteh, Jabalameli; Somayeh, Yaslianifard; Mehdi, Mirzaii

effects of berberine and palmatine on efflux pumps inhibition with different gene patterns in Pseudomonas aeruginosa isolated from burn infections

Seyed, Aghayan; Hamidreza, Mogadam; Mozhgan, Fazli; Davood, Darban Sarokhalil; Seyed, Khoramrooz; Fereshteh, Jabalameli; Somayeh, Yaslianifard; Mehdi, Mirzaii.

AJMB-Avicenna Journal of Medical Biotechnology. 2017; 9 (1): 2-7

in English | IMEMR | ID: emr-185805

ABSTRACT

ABSTRACT

Background:

Related Multidrug Resistance [MDR] to efflux pumps is a significant problem in treating infections caused by Pseudomonas aeruginosa [P. aeruginosa]. Plant compounds have been identified as Pump Inhibitors [EPIs]. In the current study, the potential effect of Berberine and Palmatine as EPIs were investigated on efflux pump inhibition through focusing on different gene patterns in P. aeruginosa isolated from burn infections

Subject(s)

Pseudomonas aeruginosa/genetics; Genes, MDR/drug effects; Berberine/therapeutic use; Plant Extracts/therapeutic use; Berberine Alkaloids; Iran

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Index: IMEMR (Eastern Mediterranean) Main subject: Pseudomonas aeruginosa / Berberine / Berberine Alkaloids / Plant Extracts / Genes, MDR / Iran Country/Region as subject: Asia Language: English Journal: Avicenna J. Med. Biotechnol. Year: 2017

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