Comparison of prooxidant-antioxidant balane between patients with high grade gliomas [IV] and control group

ABSTRACT

Background and Aim: the most common primary brain tumors of the central nervous system are gliomas. Among a number of different biomolecular events, a strong relation between oxidative stress pathways and the development of this cancer has been proved. Oxidative stress [OS] is the consequence of an imbalance between pro-oxidants and antioxidants towards pro-oxidants. The pro-oxidants cause lipid peroxidation of cell membranes, protein, DNA oxidation and changes in brain cell growth. In this study, the pro-oxidant-antioxidant balance [PAB] was determined in patients with gliomas