Correlation of fear memory in a PTSD animal model and hippocampal BDNF in response to beta-estradiol treatment

ABSTRACT

The most important characteristics of PTSD, as an anxiety disorder, are memory disorders and hippocampus is one of the essential structures which plays a critical role in PTSD memory disorders. Traumatic events cause apoptosis and alter the expression of neurotrophic factors in hippocampus. The aim of this study is to evaluate the effects of beta-Estradiol on behavioral responses in PTSD and to study its biochemical and histological mechanisms