Effects of hydrogen peroxide oxidative stress on the pattern of pro-apoptotic and anti-apoptotic genes expression during PC12 cells differentiation

ABSTRACT

Background and Aims: in neurodegenerative disorders,oxidative stress mediated by reactive oxygen species is strongly associated with increased neuronal damages which can lead to apoptosis. Pro-apoptotic and anti-apoptotic gene expressions are changed during the cell differentiation that affect cell viability and differentiation. Therefore, this study was conducted to determine the effects of hydrogen peroxideinduced oxidative stress on the apoptotic cell death in the differentiated rat pheochromocytoma [PC12] cells