Complexation of ibuprofen with water soluble p-sulfonatocalix [4]arene: a potential candidate for drug delivery application
Pakistan Journal of Pharmaceutical Sciences. 2017; 30 (3): 783-788
in English
| IMEMR
| ID: emr-186473
ABSTRACT
Complexation of ibuprofen with water soluble p-sulfonatocalix[4]arene [3] was evaluated. Both molecules exhibit a host and guest type complexation. pH, complex stoichiometry and binding constant were determined by UV-Vis and FT-IR spectroscopy. The maximum complexation of 3 with ibuprofen occurs at pH 2. Stability constant values [9.897] show that there is favorable complex formed due to vital role of p-sulfonatocalix[4]arene, while the thermodynamic parameters, i.e. [Delta]G, [Delta]H and [Delta]S have been found as -24.09 KJ/mol, 0.012 KJ/mol and 0.12 KJ/mol. K, respectively. The results show that 3 has efficiency to carry the drug at particular conditions and can be used for drug delivery as a carrier
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Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2017
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