Evaluation of nephroprotective activity of Musa paradisiaca L. in gentamicin-induced nephrotoxicity

ABSTRACT

The objective of the study was to investigate the nephroprotective activity of methanolic extract of different morphological parts [bract, flower, trachea and tracheal fluid] of Musa paradisiaca L. [Family Musaceae] against gentamicin-induced nephrotoxicity in mice. Gentamicin produced significant changes in biochemical [increased levels of blood urea nitrogen level, blood urea, and serum creatinine], and histological parameters in mice. Treatment with methanolic extract of bract [100 and 250mg/kg, b.w] and flowering stalk [trachea] [250 and 500mg/kg, b.w] significantly prevented biochemical and histological changes produced by gentamicin toxicity. The extracts of M. paradisiaca[bract and flowering stalk] could contribute a lead to discovery of a new drug for the treatment of drug-induced nephrotoxicity