Impact of bovine and human serum albumin on curcumin in vitro activity against Staphylococcus aureus

ABSTRACT

This study evaluated the impact of pH [7.4 and 6.5], bovine serum albumin [BSA], and human serum albumin [HSA] on Curcumin activity against 2 reference, 1 clinical, and 10 environmental strains of Staphylococcus aureus [S. aureus]. Minimal inhibitory concentrations [MICs] of Curcumin against S. aureus were statistically indifferent [p>0.05] at pH7.4 and pH6.5. Activity of Curcumin against S. aureus was reduced by two folds in the presence of 1.25-5% BSA/HAS