Prognostic importance of C-KIT mutations in core binding factor acute myeloid leukemia: a systematic review

ABSTRACT

Acute myeloid leukemia [AML] is defined as leukemic blast reproduction in bone marrow. Chromosomal abnormalities form different subgroups with joint clinical specifications and results. t[8;21][q22;q22] and inv[16][p13;q22] form core binding factor- AML [CBF-AML]. c-kit mutation activation occurs in 12.8-46.1% of adults with CBF leukemia. These mutations occur in 20-25% of t[8;21] and 30% of inv[16] cases