Lipid profile in end stage renal failure in relation to low protein diet and some antihypertensive drugs

ABSTRACT

This study was carried out to evaluate the serum lipid profile in hemodialysed patients and try to find out the effect of restricted protein diet, nifedepine and nadolol on them. 40 subjects were included, 10 control [group 1] and 30 end stage renal failure patients divided into 3 groups, [groups II with restricted protein diet, group III with nifedipine administration and group IV with nadolol administration]. Serum triglyceride, cholesterol, high density lipoprotein cholesterol [HDL-C] low density lipoprotein cholesterol [LDL-C], very low density lipoprotein cholesterol [VLDL-C], apolipoprotein A[1] [APO A[1]] and apolipoprotein B [APO B] were measured in all subjects. Serum triglyceride and APO B were significantly increased, while serum HDL-C decreased significantly in hemodialysed patients than control and no significant change in other lipograms. We found that serum triglyceride was significantly decreased while HDL-C significantly increased by moderate dietary protein restriction [12 months duration] in hemodialysed patients. Serum triglyceride and VLDL-C were significantly decreased while HDL-C significantly increased by 3 months nifedipine administration. Also we found a significant elevation of serum triglyceride, VLDL-C and APO B by nadolol administration [3 months] while the other serum lipograms were not significantly affected