Delayed liver regeneration after partial hepatectomy in aged Nos2 knockout mice

ABSTRACT

Objective: Patients over 60 years of age have higher mortality and morbidity after major liver resections. Nitric oxide [NO] derived from the catalytic activity of Nos2 plays a beneficial role in liver regeneration [LR] after partial hepatectomy [PH]. In this experiment, we evaluated the effect of Nos2 knockout [KO] on LR in aged mice after PH