Comparative proteomic analysis of tumor mesenchymal-like stem cells derived from high grade versus low grade gliomas

ABSTRACT

Objective: Gliomas are the most common primary brain tumors, and have been ranked as the fourth leading cause of cancer death. Tumor mesenchymal-like stem cells [tMSCs] contribute to the aggressive behavior of glial tumors by providing a favorable microenvironment for the malignant cells. The aim of our study was to identify differential proteome of tMSCs derived from low vs. high grade glioma tumors