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Correlation between hepatitis C viral load and hepatitis C Core antigenaemia among Egyptians
EMHJ-Eastern Mediterranean Health Journal. 2017; 23 (4): 280-286
in English | IMEMR | ID: emr-186906
ABSTRACT
Hepatitis C virus [HCV] infection is widespread in Egypt. This study compared HCV RNA with HCVcAg for the detection and quantification of viraemia among a sample of Egyptians. Sera from 80 suspected HCV-positive individuals were tested simultaneously for HCV-RNA load using real-time polymerase chain reaction [PCR] and HCVcAg level using ELISA. Of the 80 samples, 25% were HCV-RNA-negative. HCVcAg was detected in all samples range 0.4-2462 ng/mL, mean 460 [SD 506] ng/mL. The sensitivity and specificity of HCVcAg were 96.7% and 90.9%, respectively. There was a significant correlation between serum HCV-RNA and HCVcAg levels [r = 0.4, P < 0.0001]. HCV-RNA remains the gold standard for diagnosis of active HCV infection but HCVcAg can be used where PCR is not available
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Index: IMEMR (Eastern Mediterranean) Main subject: RNA, Viral / Polymerase Chain Reaction / Hepatitis C / Hepacivirus / Hepatitis C Antigens / Hepatitis C Antibodies Limits: Adult / Female / Humans / Male Language: English Journal: East Mediterr Health J. Year: 2017

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Index: IMEMR (Eastern Mediterranean) Main subject: RNA, Viral / Polymerase Chain Reaction / Hepatitis C / Hepacivirus / Hepatitis C Antigens / Hepatitis C Antibodies Limits: Adult / Female / Humans / Male Language: English Journal: East Mediterr Health J. Year: 2017