Genetic study of primary congenital glaucoma in Sharkia

ABSTRACT

This study included 20 normal subjects as a control group and 20 cases suffering from primary congenital glaucoma. There were 4 familial cases, 4 cases with other ocular and systemic anomalies, 6 cases exposed to prenatal environmental factors and consanguinity was detected in 9 cases. Karyotyping revealed chromosomal anomalies in 3 cases of primary congenital glaucoma, this was in the form of chromatoid breaks in 2 cases and trisomy 13 in one case. All the 3 cases were exposed to prenatal environmental factors and have other ocular and systemic anomalies. Pedigrees analysis revealed that primary congenital glaucoma was inherited as multifactorial mode of inheritance