Association of TNF-related apoptosis inducing ligand receptor [TRAIL-R] gene polymorphisms in Iranian Azeri patients with multiple sclerosis

ABSTRACT

Introduction: Multiple sclerosis [MS] is a chronic inflammatory demyelinating disorder of the central nervous system with various degrees of axonal damage. The TNF-related apoptosis inducing ligand receptor [TRAIL-R] might be playing an important role in the pathogenesis of MS. The objective of our study was to evaluate the association of two common polymorphisms is located in the TRAIL-R1 and TRAIL-R2 gene, in the pathogenesis of MS