Antithyroid drug or hypothyroidism causes cellular damage in the renal cortex of adult male albino rats: a histological and immunohistochemical study

ABSTRACT

Introduction: Thyroid and kidney functions interact with each other in the respective organ's diseased states. Drugs used to treat the respective diseases may have adverse effects on the other organ's functions. Antithyroid drugs cause hypothyroidism as well as renal dysfunction through immune mechanisms. The extrathyroidal effects of antithyroid drugs could contribute to oxidative stress and nitrosative stress and to cellular damage in the kidney