Proliferative index and p53 expression in breast carcinoma and their correlation to clinico-pathological parameters

ABSTRACT

Background: Breast cancer is the most frequently diagnosed cancer and the most common cause of cancer deaths in women worldwide. Ki67 is a biomarker that reflects cell proliferation. Despite a clear understanding of the structure and properties of this protein, its functional role remains elusive. Gene expression alteration confers the potential for invasive growth in the preinvasive stages of breast cancer. Altered expression of the tumor suppressor gene p53 is frequently seen in carcinomas of the breast and correlates with poor prognosis. This study aims to investigate Ki67 and p53 expressions in benign, preinvasive and invasive breast lesions and to correlate their expressions with the clinico-pathological parameters