Topical use of benzydamine HCL for management of oral ulcerative lesions

ABSTRACT

The objective of this study was to investigate the local anesthetic propertyof 0.75% w/v concentration benzydamine hydrochloride to control pain in avariety of painful oral ulcerative conditions. Sixty-three patients ranged in age from 14-64 years, with no history of either recent systemic or topical medication were included in this study. Diminished pain perception began at 1 min after the application of the test drug and increased gradually, started at the tongue, floor of mouth, inner surface of the lip, cheeks, soft palate then hard palate. After 10 min pain sensation was completely relieved in 49 out of 63 patients. The other 14 patients were suffering from pain in spite of anesthesia felt in the surrounding tissue away from the lesion and they were all suffering from deep extensive ulcers. 16 patients of the 63 volunteers complained from burning sensation just after the application, but by about 10 min, the burning sensation decreased with increasing anesthetic effect. The initial level of pain perception started to be regained 30 min after application and reached the initial level after 1-1.5.hours