Homoisoflavonoids and the antioxidant activity of ophiopogon japonicus root
IJPR-Iranian Journal of Pharmaceutical Research. 2017; 16 (1): 357-365
in English
| IMEMR
| ID: emr-187976
ABSTRACT
The root of Ophiopogon japonicus has been used as a traditional Chinese medicine and also a functional food ingredient for a long time in China. In the present study, 17 different homoisoflavonoid compounds were identified in the root extract of O. japonicus by HPLC-DAD and LCMS/MS analyses. The antioxidant activity of the of chloroform/methanol [11, v/v], methanol and 70% ethanol extracts, and two major isolated homoisoflavonoid compounds [methylophiopogonanone A and methylophiopogonanone B] from O. japonicus root were investigated by various in-vitro assays. Methylophiopogonanone B showed the highest antioxidant ability according to four antioxidant methods. Among the extracts, the chloroform/methanol extract which contained high amounts of homoisoflavonoids was found to exhibit the strongest antioxidant activity. The results showed that O. japonicus root can be regarded as a potential source of homoisoflavonoids and natural antioxidant
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Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
Iran. J. Pharm. Res.
Year:
2017
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