Histological changes of the dental pulp of rat after estrogen and progesterone administration

ABSTRACT

In response to the parental administration of estrogen and/or progesterone, atdifferent doses, the pulp showed dramatic regressive alterations which couldbe categorized into; edematous vacuolization of the odontoblastema associatedwith the displacement of odontoblasts and their nuclei, and the elaboration ofnodular or diffused vascularized tissue hyperplasia. The individualadministration of estrogen produced more generous pulp regression than thatshowed with progesterone. The regressive effects of the individualadministration of either of these hormones were more or less dramaticallyreversed when both of them were simultaneously administered. Theantiestrogenic potentiality of progesterone to control the unrestrainedpernicious influences of estrogen on the pulp tissue was highly determinedwhen administered in combination with estrogen only at a properproportional measures. However, it seems that the presence of both hormonesin a symbiotic condition would be essential for the maintenance and integrityof the normal structure of the dentin-pulp complex