Hepatitis E virus seroprevalence in pregnant women in Pakistan: maternal and fetal outcomes
EMHJ-Eastern Mediterranean Health Journal. 2017; 23 (8): 559-563
in English
| IMEMR
| ID: emr-188176
ABSTRACT
Hepatitis E virus [HEV] is endemic in Pakistan. Although otherwise asymptomatic, HEV infection becomes fatal in pregnancy, with considerable maternal and fetal morbidity and mortality. We conducted a descriptive study from April to October 2015 in 10 tertiary care hospitals throughout Pakistan to determine maternal and fetal morbidity and mortality in HEV-positive pregnant women with acute jaundice or raised liver function tests. Twenty-one of 135 women were HEV positive and in 3rd trimester except for 1 in 1st trimester. Overall prevalence of HEV in pregnancy was 0.19%. Ten women were artificially induced, 3 had premature labour, 4 delivered spontaneously [full term], 3 died and there was 1 intrauterine death. One woman had a home abortion before coming to hospital. There were 7 perinatal infant deaths 4 intrauterine, 3 stillbirths and 1 abortion. Maternal mortality was significantly associated with delivery, as 17 mothers who lived went into labour spontaneously or were artificially induced, whereas 3 women who continued their pregnancy and did not deliver, died. Case fatality rate of HEV infection in pregnancy was 14.2%
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Pregnancy
/
Pregnancy Outcome
/
Seroepidemiologic Studies
/
Maternal Mortality
/
Prevalence
/
Morbidity
/
Hepatitis E virus
/
Pregnant Women
/
Fetus
/
Tertiary Care Centers
Type of study:
Prevalence study
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
East Mediterr Health J.
Year:
2017
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