Synthesis and Antimicrobial activity of some new 3-amino-1,2,4-triazine amino acid derivatives

ABSTRACT

The synthesis of some 3-[N-tosyl- and N-phthaloylaminoacyl]amino-1, 2, 4-triazines [II-XIV] was described. Coupling of N-tosyl-or N- phthaloylamino acids with 3-amino-1, 2, 4-triazine using dicyclohexylcarbodiimide furnished the desired derivatives [II-XIV]. Hydrazinolysis of 3-[N-phthaloyl-Gly] aminotriazine [IX] in ethanol afforded the free amino-compound 3-[Gly] aminotriazine [XV]. Compounds XVI-XX were obtained under similar conditions. The different 3-[N-Tos-di- and tripeptidyl]aminotriazines XXI-XXVI were obtained via the azide method. Some of the prepared compounds were found to be active against a number of microorganisms