Tumor necrosis factor-alpha and procalcitonin level variations in the serum and their effects on organ function in patients with severe acute pancreatitis during infected stage

ABSTRACT

To investigate the changes of tumor necrosis factor-alpha [TNF-alpha] and procalcitonin [PCT] in the serum and their effects on organ function in patients with severe acute pancreatitis [SAP] during infected stage, aiming to provide a reference to individual treatment. 32 patients with SAP during infected stage admitted to the Digestive Department of The Second Affiliated Hospital of Zhengzhou University from April 2014 to May 2015 and also 30 volunteer normal people were recruited in this study. And 26 patients detected with positive pathogenic bacteria were grouped into group A and another 6 patients with negative pathogenic bacteria into group B and 30 normal people into group C. And TNF-alpha and PCT level in the serum and the liver, kidney and lung function and the relationship between them of all the included people were compared and analyzed. the serum TNF-alpha level detected in the bile, urine and the surface of wound in group A was much higher than that in group B [P<0.05]; and there was no significant difference in PCT between group A and group B; and TNF-alpha and PCT level in the serum in group A and group B were remarkably higher than group C [P<0.05]. In addition, the organ function [the liver, kidney and lung] in the patients with high TNF-alpha level [High TNF-alpha group] was significantly different from the patients with low TNF-alpha level [Low TNF-alpha group] [P<0.05]. And various organ functional indexes increased significantly in the patients with high PCT level [P<0.05]. There were two kinds of TNF-alpha level [high level and low level] in the patients during SAP general infection stage, and the high level may reduce various organ function, the low level can contribute to the regular inflammatory response. And there is a high PCT level in the early SAP infection stage, which can be used to predict the patients' condition