Clinical study of water drinking test and 24-hour intraocular pressure monitoring in patients with primary open angle glaucoma

ABSTRACT

This paper aims to observe the relevance of 24-hour intraocular pressure [IOP] monitoring and water drinking test [WDT] in patient with primary open angle glaucoma [POAG]. 55 patients [90 eyes] with POAG was selected and randomly divided into operation group an drug group. Operation group, with 30 cases [48 eyes], were treat with trabeculectomy. And the other 25 cases [42 eyes] were treat with antiglaucoma medication. 24-hour intraocular pressure and WDT were measured before treatment and 6 months after treatment. The correlation between the peak value of 24- hour intraocular pressure [IOP] and intraocular pressure [IOP] fluctuation and the drinking water test were analyzed. Pearson correlation analysis showed a strong positive correlation between the peak value of diurnal IOP and the peak value of WDT IOP [r=0.758]; and the Pearson correlation analysis also showed a strong positive correlation between the peak value of diurnal IOP and the peak value of WDT IOP after 6 months of POAG surgery or drug therapy [r=0.759,0.712]. The peak value of IOP and IOP fluctuation in operation group were lower than those in the drug group at 6 months after operation, the difference was statistically significant. The peak value of WDT IOP can reflect the curve peak value of 24-hour IOP, which can be used to evaluate the current treatment. There were significant differences in IOP and IOP fluctuation between the drug group and the operation group at 6 months after treatment. Operation groups could achieve lower IOP and IOP fluctuation