Expression of MMTV-like env gene in Egyptian breast cancer patients
EJMM-Egyptian Journal of Medical Microbiology [The]. 2013; 22 (2): 67-72
in English
| IMEMR
| ID: emr-188937
ABSTRACT
Mouse mammary tumor virus [MMTV] causes breast cancer in mice. DNA sequences related to MMTV-like env gene is detected in human breast cancer [EC] tissue suggesting its etiology in human BC. The objective of our study was to assess the significance of MMTV-like env gene in Egyptian BC women. One hundred and fifty archival formalin-fixed paraffin embedded breast tissues were used and divided into 2 groups; group one included 100 malignant, group two included50 benign tissues. To amplify the MMTV-like env gene, semi-nested PCR was used and to confirm the homology with the MMTV genome direct sequencing was used. MMTV-like env was efficiently detected in36%ofmalignantand 4% of benign breast tissues. Sequence analysis was evident revealed 96% homology with the MMTV genome, but no other significant similarities with the human genome
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Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
Egypt. J. Med. Microbiol.
Year:
2013
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