Null association of maternal MTHFR A1298C polymorphism with Down syndrome pregnancy: an updated meta-analysis
Egyptian Journal of Medical Human Genetics [The]. 2017; 18 (1): 9-18
in English
| IMEMR
| ID: emr-189211
ABSTRACT
Background:
Methylenetetrahydrofolate reductase [MTHFR] is an important enzyme of folate/homocysteine pathway and is essential for DNA synthesis and methylation. MTHFR gene polymorphisms have been reported as risk factors for congenital defects and several metabolic and neurological disorders. Several studies have investigated an association between maternal MTHFR A1298C polymorphism and Down syndrome [DS] child. However, results have been inconclusive
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Polymorphism, Genetic
/
Pregnancy
/
Case-Control Studies
/
Meta-Analysis as Topic
/
Methylenetetrahydrofolate Reductase (NADPH2)
/
Folic Acid
/
Homocysteine
Limits:
Female
/
Humans
Language:
English
Journal:
Egypt. J. Med. Hum. Genet.
Year:
2017
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