Construction of various gamma 34.5 deleted fluorescent-expressing oncolytic herpes simplex type 1 [oHSV] for generation and isolation of HSV-based vectors
IBJ-Iranian Biomedical Journal. 2017; 21 (4): 206-217
in English
| IMEMR
| ID: emr-189230
ABSTRACT
Background:
Oncolytic herpes simplex virus [oHSV]-based vectors lacking gamma 34.5 gene, are considered as ideal templates to construct efficient vectors for [targeted] cancer gene therapy. Herein, we reported the construction of three single/dually-flourescence labeled and gamma 34.5-deleted, recombinant HSV-1 vectors for rapid generation and easy selection/isolation of different HSV-Based vectors
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Oncolytic Viruses
/
Homologous Recombination
/
Flow Cytometry
/
Microscopy, Fluorescence
Language:
English
Journal:
Iran. Biomed. J.
Year:
2017
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