Sensitive colorimetric method for the determination of bamipine hydrocholoride

ABSTRACT

A simple and rapid colorimetric method for the determination of bamipine hydrochloride, in powder and in tablet forms, was presented. The method was based on the reaction between bamipine hydrochloride and 3-methyl-2-benzothiazolone hydrazone hydrochloride, in the presence of ferric chloride, to give a blue color with a maximum absorbance at 606 nm and a second-derivative peak-trough at 626-600 nm. Beer's Law is obeyed over a concentration range of 0.4-2.4 mug ml -1 and 0.2- 1.2 mug ml -1 for the two techniques, respectively. The method has been applied for the determination of the drug in powder and in tablets and proved to be reproducible with coefficient variation less than 1%