Synthesis of 3-chloro-7-methoxy-9-substituted acridine derivatives as pot entail Antimicrobial agents
Alexandria Journal of Pharmaceutical Sciences. 1991; 6 (1): 11-14
in English
| IMEMR
| ID: emr-18933
ABSTRACT
Three series of 3-chloro-7-methoxy-9-substituted acridine derivatives II-IV were prepared for potential antimicrobial activity. The first series, compounds IIa-i, was prepared via the reaction of I with different aromatic amines. The second, compounds IIIa-i, were obtained by the treatment of I with different phenolic compounds; while the third series, compounds IVa-c, involved reaction of I with different heterocyclic thiols viz. benzothiazole-2-thiol, benzimidazole-2-thiol and uracil-2-thiol. The structure of the novel products was substantiated by spectral and microanalytical data. Nine new compounds were tested for in vitro antimicrobial activity
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Pharmacology
Language:
English
Journal:
Alex. J. Pharm. Sci.
Year:
1991
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