Hepatotoxic effects of some synthesized aralkylamine compounds with possible dopaminergic activity

ABSTRACT

The effects of four aralkylamine compounds, synthesized as possible dopamine antagonists, were assessed on some biochemical parameters taken as markers for hepatotoxicity. For comparative purposes, apomorphine, metoclopramide and phencyclidine [PCP] were included in this study. Ketamine was also tested due to its close chemical structure to PCP. The investigated parameters were glutathione, lipid peroxidation, aspartate aminotransferase and alanine aminotransferase. Direct involvement of the hepatotoxicity was most apparent with apomorphine. The synthesized compounds I, II, III and IV showed much less hepatotoxic effects than the other known tested compounds. This lack of effect would make their clinical application quite attractive, depending on their intrinsic activity