Synthesis, acute toxicity, analgesic activity and cytotoxicity of Some bisthiourea derivatives
Pakistan Journal of Pharmaceutical Sciences. 2017; 30 (4): 1351-1356
in English
| IMEMR
| ID: emr-189705
ABSTRACT
Bisthiourea derivatives were synthesized by the reaction of benzoylisothiocyanate and diamines to give 1,2-Bis [N'-benzoylthioureidobenzene [1], l,3-di[benzoylthioureido] benzene [2] and l,4-di [benzoylthioureido] benzene [3] in acetone. Acute toxicity study revealed that LD[50] of compound [1] and [3] is 120 mg/kg body weight. Visceral pain induced by injecting i.p acetic acid in mice were strongly inhibited by all the compounds. 94.65, 95.25 and 85.54% analgesic activity were observed in compounds [1], [2] and [3] at 15 mg/kg and [2] and [3] shows 97.63 and 96.42% at 30 mg/kg body weight respectively while [1] gives 100% analgesic activity. 100% cytotoxicity was observed in compounds [2] and [3] and 96% in compound [1] at 750 ppm. The results suggest that these compounds may have potential values for treatment of cancer and painful disorders
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
In Vitro Techniques
/
Toxicity Tests, Acute
/
Visceral Pain
/
Analgesics
/
Mice
Limits:
Animals
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2017
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