Anti-Inflammatory and antiviral effects of water-soluble crude extract from Phragmites australis in vitro
Pakistan Journal of Pharmaceutical Sciences. 2017; 30 (4): 1357-1362
in English
| IMEMR
| ID: emr-189706
ABSTRACT
Phragmites australis [P. australis], a world wide distributed wetland grass, is traditionally used as food-making helper and spice in China. The pharmacological effect of this plant is poorly understood. Here, we demonstrated that lipopolysaccharide [LPS]-induced production of inflammatory mediators nitric oxide [NO] and reactive oxygen species [ROS], and the pro-inflammatory cytokines tumor necrosis factor-a [TNF-alpha] and interleukin-lp [IL-1P] in RAW264.7 macrophage were significantly inhibited by the crude extract. The inflammation pertinent signaling extra cellular signal-regulated kinase 1/2 [Erkl/2], P38MAPK, C-Jun and NF-kappaB [NF-KB] activated by LPS could be dramatically inhibited by this extract. It also remarkably inhibited bovine herpes virus type 1 [BoHV-1] replication in MDBK cells. Taken together, here, for the first time we provided P. australis
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Antiviral Agents
/
In Vitro Techniques
/
Plant Extracts
/
Spices
/
Plant Structures
/
Complex Mixtures
/
Anti-Inflammatory Agents
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2017
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