Effects of two functionally important SLCO1B1 gene polymorphisms on pharmacokinetics of atorvastatin
Pakistan Journal of Pharmaceutical Sciences. 2017; 30 (4): 1363-1370
in English
| IMEMR
| ID: emr-189707
ABSTRACT
Organic anion transporter polypeptide 1B1 [OATP1B1] encoded by [SLCO1B1] gene, an uptake transporter involved in the transport of drugs and endogenous compounds and located in hepatocyte sinusoidal membrane. Objective of study was to investigate the effects of two functionally significant SNPs [388A>G and 521T>C] and their respective genotypes of SLCO1B1 gene encoding OATP1B1 on the pharmiacokinetics of atorvastatin. A total of 100 subjects divided into 6 groups as per their genotype profile were recruited. A single dose of 80mg atorvastatin was orally administered and plasma concentration measured up to 48 hours. The 388A>G and 521T>C genotypes were significantly associated with each other when compared for AUC and C[MAX] but exhibited no significant variations in T[MAX] and ti/[2]. 521 SNP is rather more strongly associated with altered pharmacokinetics of atorvastatin when compared with the 388 SNP, though the homozygous bi-allelic variant of 388 SNP also exhibited a fairly significant variation along with homozygous bi-allelic variant of 521 SNP. The inter-individual variation in pharmacokinetics can be explained by SLCO1B1 polymorphism
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Polymorphism, Genetic
/
Polymerase Chain Reaction
/
Polymorphism, Single Nucleotide
/
Organic Anion Transporters
/
Liver-Specific Organic Anion Transporter 1
Limits:
Humans
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2017
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