Evaluation of cytotoxic and antiviral activities of aqueous leaves extracts of different plants against foot and mouth disease virus infection in farming animals
Pakistan Journal of Pharmaceutical Sciences. 2017; 30 (6): 2167-2172
in English
| IMEMR
| ID: emr-189727
ABSTRACT
Cytotoxic and antiviral activity of aqueous leaves extracts of three plants Azadirachta indica, Moringa oleifera and Moms alba against Foot and Mouth disease virus [FMDV] were determined using MTT assay [3-[4, 5-Dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide]. Eight different concentrations of each plant were evaluated. Cytotoxic and antiviral activity of each extract was evaluated as cell survival percentage and results were expressed as Means +/- S.D. From the tested plant extracts, Azadirachta indica and Moringa oleifera exhibited cytotoxicity at 200 and 100 microg/ml respectively. In case of antiviral assay, Moringa oleifera showed potent antiviral activity [p<0.05] while Azadirachta indica showed significant antiviral activity in the range of 12.5-50 microg/ml and 50-100 microg/ml respectively. In contrast no anti-FMDV activity in the present study was observed with Morus alba, although all the tested concentrations were found to be safe
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Antiviral Agents
/
Plants, Medicinal
/
Plant Extracts
/
Plant Structures
/
Plant Leaves
/
Moringa oleifera
/
Sinapis
/
Azadirachta
/
Animals, Domestic
/
Phytotherapy
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2017
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