Polymorphism of MnSOD [Val16Ala] gene in pregnancies with blighted ovum: a case-control study

ABSTRACT

Background: blighted ovum is one of the most common reasons for abortion during the first three months of pregnancy. Manganese superoxide dismutase [MnSOD] is an important antioxidant enzyme in the human immune system. The gene is located on 6q25 chromosome and acts on mitochondrial matrix. In the case of mutation or inactivity of this enzyme, mitochondrial and nuclear DNA will severely be destructed. The most common polymorphism of its gene is Val16Ala