Study of serum irisin in patients with thyroid dysfunction

ABSTRACT

Background: irisin, identified as a proteolytic cleavage product of the fibronectin type III domain-containing protein 5 [FNDC5], It is a novel myokine secreted by contracting skeletal muscle, possibly mediating some exercise health benefits via "browning" of white adipose tissue. Irisin causes a significant increase in total body energy expenditure and resistance to obesity-associated insulin resistance in mice, while controversy still exists concerning irisin origin, regulation and function in humans