toxic effects of cyclosporine on splenic tissue of rat and it's amelioration with Nigella sativa

ABSTRACT

Background: Cyclosporine is an immunosuppressive drug. Its mechanism of action is inhibition of T cells activation. Cyclosporine has toxic effects on many organs including spleen. Nigella sativa is an immunomodulatory agent. It increases lymphocyte population and also has promising anti-oxidative effects