Evaluation of serum interleukin-21 and HLA-C1 polymorphism in pediatrician hematopoietic stem cell transplantation for early diagnosis of acute graft-versus-host disease

ABSTRACT

Background: Allogenic hematopoietic stem cell transplantation [HSCT] is a strategy used for treatment of different malignant diseases. However, success of allo-HSCT can be hampered by graft-versus-host-disease [GVHD]. Natural killer [NK] cells may play an important role in activating antigen presenting cells and subsequent activation of T cells. The main purpose of this study was the evaluation of IL-21, as a blood biomarker, for early detection of acute GVHD [aGVHD] in children after HSCT and also the study of human leukocytes antigen [HLA]-C1 polymorphism, as a targeting ligand for NK cells in these patients