Thiol-disulfide homeostasis in acute appendicitis

ABSTRACT

This study aimed to assess the diagnostic value of thiol-disulfide homeostasis in patients with acute appendicitis [AA]. A total of 43 patients diagnosed with acute appendicitis in the emergency department and 59 healthy individuals were evaluated. Age, gender, white blood cell count, and thiol-disulfide homeostasis parameters [native thiol, total thiol, disulfide, disulfide/native thiol, native thiol/total thiol, and disulfide/total thiol ratios] were compared between groups. Thiol-disulfide homeostasis was determined using a newly developed method by Erel and Ne?elio?lu. White blood cell counts were statistically significantly higher in the AA group, but no significant difference [P = 0.742] was found between native thiol, total thiol, and disulfide levels of the patient and control groups. Also, no statistically significant difference was observed in disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios [P = 0.117] between groups. This was thought to be a result of early diagnosis of AA in patients at the emergency department. Hence, the inflammatory response did not increase significantly at the time of diagnosis