chronic myeloid leukemia with a unique variant philadelphia chromosome translocation: t [9; 22; 19] [q34; q11.2; p13]

ABSTRACT

Chronic myeloid leukemia [CML] is categorized as one of the myeloproliferative neoplasms, according to the World Health Organization [WHO] myeloid neoplasms and acute leukemia classification. The hallmark of this disease is the presence of a reciprocal translocation between the long arms of chromosomes 9 and 22 [t[9;22][q34;q11]] which leads to the formation of the Philadelphia chromosome [Ph] and is present in 90%-95% of CML patients. In 5%-10% of CML cases, there are variants where one or more different chromosomes are involved in addition to chromosome 9 and 22. We present a patient with newly diagnosed CML with a rare variant translocation involving chromosomes 9, 19 and 22. To the best of our knowledge, this is the first case study to describe a variant Ph chromosome translocation in chronic phase CML in Bahrain